Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction:  Catalytic Process

Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction:  Catalytic Process

The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesi...

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Veröffentlicht in:Organic letters 2002-12, Vol.4 (25), p.4435-4438
Hauptverfasser: Choi, Hyeong-wook, Nakajima, Katsumasa, Demeke, Damtew, Kang, Fu-An, Jun, Hyuk-Sang, Wan, Zhao-Kui, Kishi, Yoshito
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chromium - chemistry
Ethers, Cyclic - chemical synthesis
Ethers, Cyclic - chemistry
Molecular Conformation
Molecular Structure
Nickel - chemistry
Stereoisomerism
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Zusammenfassung:The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesis of the C14−C26 segment of halichondrins has been developed.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026981x