A method for assessing the kinetics of evoked secretion of transmitter quanta determining the generation of multiquantum endplate currents

A number of experimental and model studies in recent years have demonstrated that changes in the time course of evoked secretion of transmitter quanta represent one of the most important presynaptic mechanisms in the modulation of synaptic transmission, leading to changes in the amplitude-time characteristics of multiquantum endplate currents (EPC). A general method for assessing the kinetics of evoked secretion of transmitter quanta is provided by measuring true synaptic delays of single-quantum EPC, which allows determination of the time at which each individual quantum is released in conditions of decreased EPC quantum composition.