Solid phase synthesis of partially protected and free peptides containing disulphide bonds by simultaneous cysteine oxidation-release from 2-chlorotrityl resin

The disulphide bridge‐containing protected peptides calcitonin (1‐10) and (Tyr1)‐somatostatin‐14 were obtained in good yields and high purity by simultaneous iodine oxidation of Cys (Trt) residues and release of the protected peptides from 2‐chlorotrityl resin.

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Bibliographische Detailangaben
Veröffentlicht in:	International Journal of Peptide and Protein Research 1991-12, Vol.38 (6), p.562-568
Hauptverfasser:	BARLOS, KLEOMENIS, GATOS, DIMITRIOS, KUTSOGIANNI, SOPHIA, PAPAPHOTIOU, GEORGIOS, POULOS, CONSTANTINE, TSEGENIDIS, THEODORE
Format:	Artikel
Sprache:	eng
Schlagworte:	2-chlorotrityl resin Amino Acid Sequence calcitonin Calcitonin - analogs & derivatives Calcitonin - chemical synthesis Calcitonin - chemistry Chemistry cysteine oxidation Disulfides - chemistry Exact sciences and technology Iodine Molecular Sequence Data Molecular Structure Organic chemistry Oxidation-Reduction peptide synthesis Peptides Peptides - chemical synthesis Peptides - chemistry Preparations and properties Resins, Synthetic solid phase synthesis somatostatin Somatostatin - analogs & derivatives Somatostatin - chemical synthesis Somatostatin - chemistry
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Beschreibung
Zusammenfassung:	The disulphide bridge‐containing protected peptides calcitonin (1‐10) and (Tyr1)‐somatostatin‐14 were obtained in good yields and high purity by simultaneous iodine oxidation of Cys (Trt) residues and release of the protected peptides from 2‐chlorotrityl resin.
ISSN:	0367-8377 1399-3011
DOI:	10.1111/j.1399-3011.1991.tb01540.x