Carnosine modifies the incidence of genetically abnormal sex cells in the testes of senescence-accelerated mice

Carnosine modifies the incidence of genetically abnormal sex cells in the testes of senescence-accelerated mice

The quantitative micronucleus test showed that the natural dipeptide carnosine increases the count of aberrant spermatogonia and round spermatids in the testes in SAMR1 mice resistant to accelerated aging by 64 and 85%, respectively, compared to the control. However, this agent did not modify the in...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2002-07, Vol.134 (1), p.78-80
Hauptverfasser: Zakhidov, S T, Gopko, A V, Semenova, M L, Mikhaleva, Ya Yu, Makarov, A A, Kulibin, A Yu
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Carnosine - metabolism
Carnosine - pharmacology
Cellular Senescence
Male
Mice
Mice, Inbred Strains
Micronucleus Tests
Spermatids - drug effects
Spermatogonia - drug effects
Testis - drug effects
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Zusammenfassung:The quantitative micronucleus test showed that the natural dipeptide carnosine increases the count of aberrant spermatogonia and round spermatids in the testes in SAMR1 mice resistant to accelerated aging by 64 and 85%, respectively, compared to the control. However, this agent did not modify the incidence of chromosome mutations in spermatogenic cells in SAMP1 mice predisposed to accelerated aging.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1020625225685