Detection of major group rhinoviruses by soluble intercellular adhesion molecule-1 (sICAM-1)

Soluble intercellular adhesion molecule-1 (sICAM-1) was shown to be the receptor for the major subgroup of rhinoviruses. It was demonstrated that this molecule can inhibit the binding and subsequent infection of target cells by rhinoviruses belonging to the major but not the minor subgroup. The data...

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Veröffentlicht in:	Journal of virological methods 1991-12, Vol.35 (3), p.255-264
Hauptverfasser:	Last-Barney, Kathleen, Marlin, Steven D., McNally, Eugene J., Cahill, Carol, Jeanfavre, Deborah, Faanes, Ronald B., Merluzzi, Vincent J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins Biological and medical sciences Biotin Cell Adhesion Molecules - metabolism Cytopathogenic Effect, Viral ELISA Enzyme-Linked Immunosorbent Assay - methods Fundamental and applied biological sciences. Psychology HeLa Cells Humans Intercellular Adhesion Molecule-1 Microbiology Receptor Receptors, Virus - metabolism Rhinovirus Rhinovirus - classification Rhinovirus - metabolism Rhinovirus - pathogenicity sICAM-1 Streptavidin Techniques used in virology Virology
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Zusammenfassung:	Soluble intercellular adhesion molecule-1 (sICAM-1) was shown to be the receptor for the major subgroup of rhinoviruses. It was demonstrated that this molecule can inhibit the binding and subsequent infection of target cells by rhinoviruses belonging to the major but not the minor subgroup. The data reported now describe an ELISA-based system utilizing biotinylated sICAM-1 as a means of detecting rhinoviruses belonging to the major subgroup.
ISSN:	0166-0934 1879-0984
DOI:	10.1016/0166-0934(91)90067-A