Role of endogenous fatty acids in the control of hepatic gluconeogenesis

Inhibition of endogenous long chain fatty acids oxidation by tetradecylglycidate (TDGA) impeded gluconeogenesis from lactate or from low concentrations of pyruvate (0.5 m m), β-hydroxybutyrate or even ethanol was capable of overcoming the inhibitory effect of TDGA in the absence of significant chang...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1992, Vol.292 (1), p.95-101
Hauptverfasser:	González-Manchón, Consuelo, Martín-Requero, Angeles, Ayuso, Matilde S., Parrilla, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Carbohydrates Epoxy Compounds - pharmacology Fatty Acids - pharmacology Fatty Acids - physiology Fatty Acids, Volatile - pharmacology Fundamental and applied biological sciences. Psychology Gluconeogenesis - drug effects Hydroxybutyrates - pharmacology Liver - drug effects Liver - metabolism Liver - physiology Male NAD Oses Other biological molecules Oxidation-Reduction - drug effects Pyruvates - metabolism Pyruvic Acid Rats Rats, Inbred Strains
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Zusammenfassung:	Inhibition of endogenous long chain fatty acids oxidation by tetradecylglycidate (TDGA) impeded gluconeogenesis from lactate or from low concentrations of pyruvate (0.5 m m), β-hydroxybutyrate or even ethanol was capable of overcoming the inhibitory effect of TDGA in the absence of significant changes in the hepatic content of acetyl-CoA. At low (
ISSN:	0003-9861 1096-0384
DOI:	10.1016/0003-9861(92)90055-2