Copper-Catalyzed Reductive Alkylations of Enones: A Novel Transmetalation Protocol

Copper-Catalyzed Reductive Alkylations of Enones: A Novel Transmetalation Protocol

Looking for an alternative to prepare your regio‐ and stereodefined boron enolates? Concerned about using expensive and moisture‐sensitive Bu2BOTf? Consider this new procedure for regiospecific enolization based on a catalytic CuH‐initiated 1,4‐reduction followed by in situ transmetalation with a si...

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Veröffentlicht in:Angewandte Chemie International Edition 2002-12, Vol.41 (23), p.4580-4582
Hauptverfasser: Lipshutz, Bruce H., Papa, Patrick
Format: Artikel
Sprache:eng
Schlagworte:
boron
copper
hydrides
reduction
transmetalation
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Zusammenfassung:Looking for an alternative to prepare your regio‐ and stereodefined boron enolates? Concerned about using expensive and moisture‐sensitive Bu2BOTf? Consider this new procedure for regiospecific enolization based on a catalytic CuH‐initiated 1,4‐reduction followed by in situ transmetalation with a simple borane (R$\rm{^{{\prime}}_{{2}}}$BH; see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20021202)41:23<4580::AID-ANIE4580>3.0.CO;2-7