Lipoprotein lipase: genetics, lipid uptake, and regulation

Lipoprotein lipase: genetics, lipid uptake, and regulation

Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver,...

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Veröffentlicht in:Journal of lipid research 2002-12, Vol.43 (12), p.1997-2006
Hauptverfasser: Merkel, Martin, Eckel, Robert H, Goldberg, Ira J
Format: Artikel
Sprache:eng
Schlagworte:
Chylomicrons - blood
Gene Expression Regulation - physiology
Genetic Variation
Humans
Lipoprotein Lipase - genetics
Lipoprotein Lipase - metabolism
Liver - metabolism
Mutation
Myocardium - metabolism
Nervous System - metabolism
Organ Specificity
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Zusammenfassung:Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.
ISSN:0022-2275
DOI:10.1194/jlr.R200015-JLR200