ERKs, extracellular signal-regulated MAP-2 kinases

A family of protein kinases, known alternatively as microtubule-associated protein-2/myelin basic protein kinases or extracellular signal-regulated kinases, is activated by numerous hormones, growth factors and other extracellular stimuli. At least two members of this family function as intermediate...

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Veröffentlicht in:	Current opinion in cell biology 1991-12, Vol.3 (6), p.1025-1032
Hauptverfasser:	Cobb, Melanie H., Robbins, David J., Boulton, Teri G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinases Extracellular Space Glycogen Synthase Kinase 3 Growth Substances - metabolism Hormones - metabolism Models, Biological Phosphorylation Protein Kinases - metabolism Ribosomal Protein S6 Kinases Signal Transduction Threonine - metabolism Tyrosine - metabolism
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Beschreibung
Zusammenfassung:	A family of protein kinases, known alternatively as microtubule-associated protein-2/myelin basic protein kinases or extracellular signal-regulated kinases, is activated by numerous hormones, growth factors and other extracellular stimuli. At least two members of this family function as intermediate kinases in protein phosphorylation cascades. Their mechanisms of activation may involve autophosphorylation, which occurs on both threonine and tyrosine residues.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/0955-0674(91)90124-H