The dynamics of cell cycle regulation
Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical...
Gespeichert in:
| Veröffentlicht in: | BioEssays 2002-12, Vol.24 (12), p.1095-1109 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1109 |
|---|---|
| container_issue | 12 |
| container_start_page | 1095 |
| container_title | BioEssays |
| container_volume | 24 |
| creator | Tyson, John J. Csikasz-Nagy, Attila Novak, Bela |
| description | Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc. |
| doi_str_mv | 10.1002/bies.10191 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72711209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1566858498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4981-4e4194bd522a36d04e46d7cde60d9400553df7f0e4910868db2775d324bd2cb23</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqWw4QNQNiCEFPA4fsRLqNpSUcGCorKzEtuBQNqUuBHk73FJgV1XMyOdezU6CB0DvgSMyVWaW-c3kLCDusAIhBCLeBd1MeEslISKDjpw7g1jLDmh-6gDhFIhBeui0-mrDUyzSOa5dkGZBdoWRaAbXdigsi91kazycnGI9rKkcPZoM3voaTiY9m_DycNo3L-ehJrKGEJqKUiaGkZIEnGD_c2N0MZybCTFmLHIZCLDlkrAMY9NSoRgJiI-Q3RKoh46a3uXVflRW7dS89ytP0oWtqydEkQAECw9eL4VBMZ5zGL_lUcvWlRXpXOVzdSyyudJ1SjAau1Prf2pH38ePtn01uncmn90I8wD0AKfeWGbLVXqZjx4_C0N20zuVvbrL5NU74qLSDA1ux-pOxGz2TMMVRR9A0NEht8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1566858498</pqid></control><display><type>article</type><title>The dynamics of cell cycle regulation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Tyson, John J. ; Csikasz-Nagy, Attila ; Novak, Bela</creator><creatorcontrib>Tyson, John J. ; Csikasz-Nagy, Attila ; Novak, Bela</creatorcontrib><description>Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc.</description><identifier>ISSN: 0265-9247</identifier><identifier>EISSN: 1521-1878</identifier><identifier>DOI: 10.1002/bies.10191</identifier><identifier>PMID: 12447975</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Cell Cycle ; Cell Nucleus - metabolism ; Computer Simulation ; DNA - biosynthesis ; Eukaryotic Cells - physiology ; Humans ; Models, Biological ; Models, Theoretical ; Mutation ; Schizosaccharomyces pombe ; Time Factors ; Yeasts - physiology</subject><ispartof>BioEssays, 2002-12, Vol.24 (12), p.1095-1109</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>Copyright 2002 Wiley-Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4981-4e4194bd522a36d04e46d7cde60d9400553df7f0e4910868db2775d324bd2cb23</citedby><cites>FETCH-LOGICAL-c4981-4e4194bd522a36d04e46d7cde60d9400553df7f0e4910868db2775d324bd2cb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbies.10191$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbies.10191$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12447975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tyson, John J.</creatorcontrib><creatorcontrib>Csikasz-Nagy, Attila</creatorcontrib><creatorcontrib>Novak, Bela</creatorcontrib><title>The dynamics of cell cycle regulation</title><title>BioEssays</title><addtitle>Bioessays</addtitle><description>Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc.</description><subject>Animals</subject><subject>Cell Cycle</subject><subject>Cell Nucleus - metabolism</subject><subject>Computer Simulation</subject><subject>DNA - biosynthesis</subject><subject>Eukaryotic Cells - physiology</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Models, Theoretical</subject><subject>Mutation</subject><subject>Schizosaccharomyces pombe</subject><subject>Time Factors</subject><subject>Yeasts - physiology</subject><issn>0265-9247</issn><issn>1521-1878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqWw4QNQNiCEFPA4fsRLqNpSUcGCorKzEtuBQNqUuBHk73FJgV1XMyOdezU6CB0DvgSMyVWaW-c3kLCDusAIhBCLeBd1MeEslISKDjpw7g1jLDmh-6gDhFIhBeui0-mrDUyzSOa5dkGZBdoWRaAbXdigsi91kazycnGI9rKkcPZoM3voaTiY9m_DycNo3L-ehJrKGEJqKUiaGkZIEnGD_c2N0MZybCTFmLHIZCLDlkrAMY9NSoRgJiI-Q3RKoh46a3uXVflRW7dS89ytP0oWtqydEkQAECw9eL4VBMZ5zGL_lUcvWlRXpXOVzdSyyudJ1SjAau1Prf2pH38ePtn01uncmn90I8wD0AKfeWGbLVXqZjx4_C0N20zuVvbrL5NU74qLSDA1ux-pOxGz2TMMVRR9A0NEht8</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Tyson, John J.</creator><creator>Csikasz-Nagy, Attila</creator><creator>Novak, Bela</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>The dynamics of cell cycle regulation</title><author>Tyson, John J. ; Csikasz-Nagy, Attila ; Novak, Bela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4981-4e4194bd522a36d04e46d7cde60d9400553df7f0e4910868db2775d324bd2cb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cell Cycle</topic><topic>Cell Nucleus - metabolism</topic><topic>Computer Simulation</topic><topic>DNA - biosynthesis</topic><topic>Eukaryotic Cells - physiology</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Models, Theoretical</topic><topic>Mutation</topic><topic>Schizosaccharomyces pombe</topic><topic>Time Factors</topic><topic>Yeasts - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tyson, John J.</creatorcontrib><creatorcontrib>Csikasz-Nagy, Attila</creatorcontrib><creatorcontrib>Novak, Bela</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BioEssays</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tyson, John J.</au><au>Csikasz-Nagy, Attila</au><au>Novak, Bela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The dynamics of cell cycle regulation</atitle><jtitle>BioEssays</jtitle><addtitle>Bioessays</addtitle><date>2002-12</date><risdate>2002</risdate><volume>24</volume><issue>12</issue><spage>1095</spage><epage>1109</epage><pages>1095-1109</pages><issn>0265-9247</issn><eissn>1521-1878</eissn><abstract>Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12447975</pmid><doi>10.1002/bies.10191</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0265-9247 |
| ispartof | BioEssays, 2002-12, Vol.24 (12), p.1095-1109 |
| issn | 0265-9247 1521-1878 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72711209 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cell Cycle Cell Nucleus - metabolism Computer Simulation DNA - biosynthesis Eukaryotic Cells - physiology Humans Models, Biological Models, Theoretical Mutation Schizosaccharomyces pombe Time Factors Yeasts - physiology |
| title | The dynamics of cell cycle regulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T09%3A21%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20dynamics%20of%20cell%20cycle%20regulation&rft.jtitle=BioEssays&rft.au=Tyson,%20John%20J.&rft.date=2002-12&rft.volume=24&rft.issue=12&rft.spage=1095&rft.epage=1109&rft.pages=1095-1109&rft.issn=0265-9247&rft.eissn=1521-1878&rft_id=info:doi/10.1002/bies.10191&rft_dat=%3Cproquest_cross%3E1566858498%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1566858498&rft_id=info:pmid/12447975&rfr_iscdi=true |