Improved posthypoxic recovery with a membrane-permeable calpain inhibitor
In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. T...
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| Veröffentlicht in: | European journal of pharmacology 1991-12, Vol.209 (1), p.123-125 |
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| container_title | European journal of pharmacology |
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| creator | Arlinghaus, Lauren Mehdi, Shujaath Lee, Kevin S. |
| description | In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology. |
| doi_str_mv | 10.1016/0014-2999(91)90022-I |
| format | Article |
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The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(91)90022-I</identifier><identifier>PMID: 1814757</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Calpain - antagonists & inhibitors ; Calpain inhibitor ; Cell Death - drug effects ; Cell Membrane Permeability - drug effects ; Dipeptides - pharmacology ; Hippocampal slice ; Hippocampus - anatomy & histology ; Hippocampus - drug effects ; Hippocampus - enzymology ; Hypoxia ; Hypoxia - drug therapy ; Hypoxia - enzymology ; Medical sciences ; Miscellaneous ; Neuropharmacology ; Neuroprotection ; Pharmacology. 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The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calpain - antagonists & inhibitors</subject><subject>Calpain inhibitor</subject><subject>Cell Death - drug effects</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Dipeptides - pharmacology</subject><subject>Hippocampal slice</subject><subject>Hippocampus - anatomy & histology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - enzymology</subject><subject>Hypoxia</subject><subject>Hypoxia - drug therapy</subject><subject>Hypoxia - enzymology</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Neuroprotection</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteolysis</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFq3DAQhkVI2Wy2eYMUfAghObjVaC3LugTC0rSGhV6as5DkEatgrx3Jm3TfvnJ2SW_paWDmm-HXJ0IugX4FCuU3SqHImZTyRsKtpJSxvD4hc6iEzKkAdkrm78gZOY_xiVLKJeMzMoMKCsHFnNR1N4T-BZts6OO42Q_9H2-zgDb1wj579eMm01mHnQl6i_mAoUNtWsysbgftt5nfbrzxYx8-k09OtxEvjnVBHh--_179zNe_ftSr-3VuCxBjXhptwbHKoXXGAWO8cQBalw1U2BhJnVsa57QwBRVLlA06xsuCV5pzy1y5XJDrw92U-3mHcVSdjxbbNuXrd1EJJqiUgv4XhJKx5GkCiwNoQx9jQKeG4Dsd9gqomlSryaOaPCoJ6k21qtPal-P9nemw-bd0cJvmV8e5jsmWSwKtj-8Yp4Usq-k9dwcMk7QXj0FF63FrsfHpG0bV9P7jHH8BMDub4A</recordid><startdate>19911210</startdate><enddate>19911210</enddate><creator>Arlinghaus, Lauren</creator><creator>Mehdi, Shujaath</creator><creator>Lee, Kevin S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19911210</creationdate><title>Improved posthypoxic recovery with a membrane-permeable calpain inhibitor</title><author>Arlinghaus, Lauren ; Mehdi, Shujaath ; Lee, Kevin S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6bac1f28fecfbf1225df11aa6d18edb90ff3bffa7b4073e9def256458a55c2f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calpain - antagonists & inhibitors</topic><topic>Calpain inhibitor</topic><topic>Cell Death - drug effects</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>Dipeptides - pharmacology</topic><topic>Hippocampal slice</topic><topic>Hippocampus - anatomy & histology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - enzymology</topic><topic>Hypoxia</topic><topic>Hypoxia - drug therapy</topic><topic>Hypoxia - enzymology</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Neuroprotection</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteolysis</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arlinghaus, Lauren</creatorcontrib><creatorcontrib>Mehdi, Shujaath</creatorcontrib><creatorcontrib>Lee, Kevin S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arlinghaus, Lauren</au><au>Mehdi, Shujaath</au><au>Lee, Kevin S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved posthypoxic recovery with a membrane-permeable calpain inhibitor</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1991-12-10</date><risdate>1991</risdate><volume>209</volume><issue>1</issue><spage>123</spage><epage>125</epage><pages>123-125</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1814757</pmid><doi>10.1016/0014-2999(91)90022-I</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1991-12, Vol.209 (1), p.123-125 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Calpain - antagonists & inhibitors Calpain inhibitor Cell Death - drug effects Cell Membrane Permeability - drug effects Dipeptides - pharmacology Hippocampal slice Hippocampus - anatomy & histology Hippocampus - drug effects Hippocampus - enzymology Hypoxia Hypoxia - drug therapy Hypoxia - enzymology Medical sciences Miscellaneous Neuropharmacology Neuroprotection Pharmacology. Drug treatments Proteolysis Rat Rats Rats, Inbred Strains |
| title | Improved posthypoxic recovery with a membrane-permeable calpain inhibitor |
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