Improved posthypoxic recovery with a membrane-permeable calpain inhibitor

In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. T...

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Veröffentlicht in:	European journal of pharmacology 1991-12, Vol.209 (1), p.123-125
Hauptverfasser:	Arlinghaus, Lauren, Mehdi, Shujaath, Lee, Kevin S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calpain - antagonists & inhibitors Calpain inhibitor Cell Death - drug effects Cell Membrane Permeability - drug effects Dipeptides - pharmacology Hippocampal slice Hippocampus - anatomy & histology Hippocampus - drug effects Hippocampus - enzymology Hypoxia Hypoxia - drug therapy Hypoxia - enzymology Medical sciences Miscellaneous Neuropharmacology Neuroprotection Pharmacology. Drug treatments Proteolysis Rat Rats Rats, Inbred Strains
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Zusammenfassung:	In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(91)90022-I