Comparison of the effects of sodium pentosanpolysulfate and unfractionated heparin on venous thrombosis; an experimental study in rats

Comparison of the effects of sodium pentosanpolysulfate and unfractionated heparin on venous thrombosis; an experimental study in rats

Sodium pentosanpolysulfate (Fibrezy R) and unfractionated heparin (Liquemin R) had significant antithrombotic efficacy in rats. 1 mg/kg body weight (BW) Fibrezym R had its maximal effect 2 – 4 hours after subcutaneous administration; 200 U/kg BW Liquemin R s.c. were most effective 4 – 6 hours after...

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Veröffentlicht in:Thrombosis research 1991-11, Vol.64 (3), p.301-308
Hauptverfasser: Kiesel, J., Harbauer, G., Wenzel, E., Pindur, G., Bohnerth, St
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Dopplersonography
Embolism
Heparin
Heparin - analogs & derivatives
Heparin - therapeutic use
Male
Medical sciences
Pentosan Sulfuric Polyester - therapeutic use
Pentosanpolysulfat
Rats
Rats, Inbred Strains
Thrombophlebitis - drug therapy
Time Factors
Venous thrombosis
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Zusammenfassung:Sodium pentosanpolysulfate (Fibrezy R) and unfractionated heparin (Liquemin R) had significant antithrombotic efficacy in rats. 1 mg/kg body weight (BW) Fibrezym R had its maximal effect 2 – 4 hours after subcutaneous administration; 200 U/kg BW Liquemin R s.c. were most effective 4 – 6 hours after application. Both drugs caused frequent embolic break-offs of thrombi during the time periods of maximal antithrombotic efficiency.
ISSN:0049-3848
1879-2472
DOI:10.1016/0049-3848(91)90001-D