Chromium bound to DNA alters cleavage by restriction endonucleases
We report that the presence of chromium-DNA adducts can inhibit as well as enhance cleavage by restriction endonucleases, depending on the endonuclease involved, the DNA substrate, and the extent of chromium-DNA binding.
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Veröffentlicht in: | Chemical research in toxicology 1991-11, Vol.4 (6), p.638-641 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | We report that the presence of chromium-DNA adducts can inhibit as well as enhance cleavage by restriction endonucleases, depending on the endonuclease involved, the DNA substrate, and the extent of chromium-DNA binding. |
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ISSN: | 0893-228X 1520-5010 |
DOI: | 10.1021/tx00024a007 |