Serum deprivation-induced upregulation of voltage-dependent sodium channels in adrenal chromaffin cells: selective involvement of extracellular signal-regulated kinase pathway

In the present study, we investigated whether activation of the MAPK family could regulate the cell surface expression of Na channels in cultured bovine adrenal chromaffin cells. The results suggest that constitutively activated ERK (but not p38 or JNK), by various extracellular stimuli, down-modula...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-10, Vol.971 (1), p.153-155
Hauptverfasser:	Yanagita, Toshihiko, Kobayashi, Hideyuki, Yokoo, Hiroki, Saitoh, Tomokazu, Minami, Shin-Ichi, Shiraishi, Seiji, Uezono, Yasuhito, Wada, Akihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Chromaffin Cells - metabolism Culture Media, Serum-Free - pharmacology Enzyme Activation Immunoblotting JNK Mitogen-Activated Protein Kinases MAP Kinase Signaling System Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases Phosphorylation Protein Binding RNA, Messenger - metabolism Sodium Channels - metabolism Time Factors Up-Regulation
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Zusammenfassung:	In the present study, we investigated whether activation of the MAPK family could regulate the cell surface expression of Na channels in cultured bovine adrenal chromaffin cells. The results suggest that constitutively activated ERK (but not p38 or JNK), by various extracellular stimuli, down-modulates the density of cell surface Na channels, which was mediated via the destabilization of Na channel alpha-subunit mRNA.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2002.tb04453.x