N-[(1-LONG ALKYL-2-PYRROLIDINYL)METHYL]BENZAMIDES WITH POTENT SEROTONIN 5-HT1A RECEPTOR AFFINITIES

A series of N-(2-pyrrolidinylmethyl)-2-methoxy-5-sulfamoylbenzamide derivatives bearing a long alkyl chain at the 1-position of the pyrrolidine ring was synthesized and found to possess high affinities for serotonin 5-HT1A receptors.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/12/25, Vol.39(12), pp.3370-3372
Hauptverfasser:	IKEBE, Tsuguo, MURAKAMI, Shu, TAKEHARA, Shuzo, SAKAMORI, Masamitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT1A receptor Animals benzamide Benzamides - chemical synthesis Benzamides - pharmacokinetics Chemistry Corpus Striatum - drug effects Corpus Striatum - metabolism Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques long alkyl substituent Organic chemistry Preparations and properties pyrrolidine Pyrrolidines - chemical synthesis Pyrrolidines - pharmacokinetics Rats Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, Dopamine D2 Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism sulpiride
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Beschreibung
Zusammenfassung:	A series of N-(2-pyrrolidinylmethyl)-2-methoxy-5-sulfamoylbenzamide derivatives bearing a long alkyl chain at the 1-position of the pyrrolidine ring was synthesized and found to possess high affinities for serotonin 5-HT1A receptors.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.3370