Effects of an eicosapentaenoic and docosahexaenoic acid concentrate on a human lung carcinoma grown in nude mice

The effects of the n−3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the growth of a human lung mucoepidermoid carcinoma (HLMC) in athymic mice were studied. The mice were divided into three groups which were given either a control chow diet (C), a chow diet supplemente...

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Veröffentlicht in:Lipids 1991-11, Vol.26 (11), p.866-870
Hauptverfasser: Bravo, M. G., Antueno, R. J., Toledo, J., De Tomás, M. E., Mercuri, O. F., Quintans, C.
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Sprache:eng
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Zusammenfassung:The effects of the n−3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the growth of a human lung mucoepidermoid carcinoma (HLMC) in athymic mice were studied. The mice were divided into three groups which were given either a control chow diet (C), a chow diet supplemented with EPA/DHA (P) (25 or 50 mg of free n−3 fatty acids/g of pellet/day), or chow diet supplemented with palmitic acid (S) (isocaloric with P). Two independent experimental schedules were followed: i) host mice bearing either tumors that were allowed to reach 4000 mm3, or only 35 mm3, were fed C, P or S for 21 or 41 days; ii) animals were fed C, P and S for 9 days before tumor implant and were maintained on these diets throughout tumor growth. Food consumption, mouse weight and liver/body weight ratio showed no significant differences between supplemented diets and chow. Tumor growth was markedly inhibited (45%) in both experiments by the EPA/DHA supplemented diet. In Experiment 2, only 60% of mice fed diet P had tumors. The fatty acid composition of neutral and polar lipids of host liver and tumor reflected the dietary intake of n−3 fatty acids; the content of arachidonic acid was reduced by 50%, and EPA/DHA was increased 3‐to 5‐fold. Tumor prostaglandin E2 levels were reduced 7.4‐fold in the P group. The reduced PGE2 content may be a factor in tumor growth inhibition.
ISSN:0024-4201
1558-9307
DOI:10.1007/BF02535969