Collisional spectroscopy approaches in the characterization of 7-α- and 7-β-hydroxycholesterol

Collisional spectroscopy approaches in the characterization of 7-α- and 7-β-hydroxycholesterol

High‐ and low‐energy collision experiments, by means of double‐focusing and ion‐trap mass spectrometers, respecstively, performed on the M+˙ and [MH2O]+˙ ions of 7‐α‐ and 7‐β‐hydroxycholesterol lead to a clear structural characterization of the two stereoisomers. In particular, the β isomer shows p...

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Veröffentlicht in:Rapid communications in mass spectrometry 1991-05, Vol.5 (5), p.240-244
Hauptverfasser: Favretto, Donata, Guidugli, Federico, Seraglia, Roberta, Traldi, Pietro, Ursini, Fulvio, Sevanian, Alex
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Hydroxycholesterols
Mass spectrometry
Mass Spectrometry - methods
Organic chemistry
Reactivity and mechanisms
Stereoisomerism
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Zusammenfassung:High‐ and low‐energy collision experiments, by means of double‐focusing and ion‐trap mass spectrometers, respecstively, performed on the M+˙ and [MH2O]+˙ ions of 7‐α‐ and 7‐β‐hydroxycholesterol lead to a clear structural characterization of the two stereoisomers. In particular, the β isomer shows peculiar fragmentation pathways due to interaction between the hydroxyl group in position 7‐β and the hydrogen atom on C(15).
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.1290050507