The "Aryne" Route to Biaryls Featuring Uncommon Substituent Patterns

The "Aryne" Route to Biaryls Featuring Uncommon Substituent Patterns

1,2‐Didehydroarenes (“arynes”) mediate as extremely reactive, short‐lived intermediates in selective aryl–aryl coupling processes to form biaryls with unprecedented substituent patterns (see scheme, X=H, F, Cl). Possible applications include the synthesis of novel ligands for asymmetric catalysis....

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Veröffentlicht in:Angewandte Chemie International Edition 2002-11, Vol.41 (22), p.4272-4274
Hauptverfasser: Leroux, Frédéric, Schlosser, Manfred
Format: Artikel
Sprache:eng
Schlagworte:
aryl-aryl coupling
arynes
atropisomerism
biaryls
lithium reagents
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Beschreibung
Zusammenfassung:1,2‐Didehydroarenes (“arynes”) mediate as extremely reactive, short‐lived intermediates in selective aryl–aryl coupling processes to form biaryls with unprecedented substituent patterns (see scheme, X=H, F, Cl). Possible applications include the synthesis of novel ligands for asymmetric catalysis.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20021115)41:22<4272::AID-ANIE4272>3.0.CO;2-B