Chromium-cage complex as contrast agent in MR imaging—Biodistribution studies of the [ 57Co]cobalt analogue

The synthesis and T 1 and T 2 relaxivities of the Cr(III)-(NH 2)-Sar-cage complex is reported. An outer-sphere relaxation mechanism is postulated for the relaxivity of the complex. Tissue distribution studies in mice using a [ 57Co]cobalt analogue as a radioactive tracer showed that the complex is e...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1991, Vol.18 (8), p.855-858
Hauptverfasser:	Jackson, Graham E., Byrne, Michael J., Blekkenhorst, Gerry, Hendry, Antony J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cobalt - chemistry Cobalt - pharmacokinetics Cobalt Radioisotopes Contrast Media - chemistry Contrast Media - pharmacokinetics Contrast media. Radiopharmaceuticals Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacokinetics Kidney - metabolism Magnetic Resonance Imaging Male Medical sciences Mice Mice, Inbred BALB C Neoplasm Transplantation Pharmacology. Drug treatments Radionuclide Imaging Rhabdomyosarcoma - diagnostic imaging Sarcosine - analogs & derivatives Sarcosine - chemistry Sarcosine - pharmacokinetics Tissue Distribution
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Zusammenfassung:	The synthesis and T 1 and T 2 relaxivities of the Cr(III)-(NH 2)-Sar-cage complex is reported. An outer-sphere relaxation mechanism is postulated for the relaxivity of the complex. Tissue distribution studies in mice using a [ 57Co]cobalt analogue as a radioactive tracer showed that the complex is excreted rapidly in the urine. Some renal uptake of the complex is seen. Appreciable uptake of labelled cage complex was observed in 3-methylcholanthrene induced murine rhabdomyosarcoma.
ISSN:	0883-2897
DOI:	10.1016/0883-2897(91)90093-Z