Calcium transport proteins in active secretory zones: Na-Ca exchange isoforms and exchanger kinetic properties in chromaffin granules and plasma membranes

Calcium transport proteins in active secretory zones: Na-Ca exchange isoforms and exchanger kinetic properties in chromaffin granules and plasma membranes

We have found that Na-Ca exchange influences Ca(2+) efflux, signal decay, and the rate of secretion in chromaffin cells. We now report the presence of two distinct splicing variant isoforms of Na-Ca exchange proteins in bovine chromaffin cells and their transport properties in chromaffin granules an...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2002-10, Vol.971 (1), p.142-144
Hauptverfasser: Schneider, A S, Mah, S J, Farhadi, M, Grindi, E, Davis, K H
Format: Artikel
Sprache:eng
Schlagworte:
Alternative Splicing
Amino Acid Sequence
Animals
Biological Transport
Calcium - metabolism
Cattle
Cell Membrane - metabolism
Chromaffin Cells - metabolism
Exons
Kinetics
Molecular Sequence Data
Myocardium - metabolism
Protein Isoforms
Sequence Homology, Amino Acid
Sodium-Calcium Exchanger - chemistry
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Zusammenfassung:We have found that Na-Ca exchange influences Ca(2+) efflux, signal decay, and the rate of secretion in chromaffin cells. We now report the presence of two distinct splicing variant isoforms of Na-Ca exchange proteins in bovine chromaffin cells and their transport properties in chromaffin granules and plasma membrane vesicles.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04449.x