Preclinical evaluation of 99m technetium-labeled DD-3B6/22 FAB' for thrombus detection

Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD-3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conju...

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Veröffentlicht in:	Thrombosis research 1991-12, Vol.64 (6), p.691-701
Hauptverfasser:	WALKER, K. Z, BONIFACE, G. R, PHIPPARD, A. F, HAREWOOD, W, BAUTOVICH, G. J, BUNDESEN, P. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Drug Evaluation, Preclinical Fibrin Fibrinogen Degradation Products - immunology Immunoglobulin Fab Fragments Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Papio Phlebography Radiodiagnosis. Nmr imagery. Nmr spectrometry Radioimmunodetection Technetium - pharmacokinetics Thrombosis - diagnosis Thrombosis - metabolism
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Zusammenfassung:	Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD-3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conjugate with little accumulation of label in other organs. 99mTc-DD-3B6/22 Fab' appears a suitable candidate for further investigation as a radioimaging agent for thrombi in humans.
ISSN:	0049-3848 1879-2472