Elevation of IL‐6 in ATL Patient with a Pathological Fracture

Hypercalcemia and osteolytic bone lesion are important complications in the prognosis of patients with adult T cell leukemia/lymphoma (ATL). We report a 61‐year‐old Japanese woman who died of ATL and had multiple osteolytic lesions and pathological fractures of her extremities. Highly increased seru...

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Veröffentlicht in:	Journal of dermatology 2002-10, Vol.29 (10), p.644-647
Hauptverfasser:	Anzai, Saburo, Takayasu, Susumu, Fujiwara, Sakuhei, Tateyama, Masamichi, Taira, Hirohumi, Takashita, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	ATL Bone and Bones - pathology bone fracture Calcium - blood Female Femoral Fractures - blood Femoral Fractures - etiology Fractures, Spontaneous - diagnostic imaging Fractures, Spontaneous - etiology Fractures, Spontaneous - pathology Humans Humeral Fractures - blood Humeral Fractures - etiology IL‐6 Interleukin-6 - blood Leukemia-Lymphoma, Adult T-Cell - blood Leukemia-Lymphoma, Adult T-Cell - complications Leukemia-Lymphoma, Adult T-Cell - pathology Middle Aged Osteolysis - blood Osteolysis - etiology Osteolysis - pathology Parathyroid Hormone - blood Parathyroid Hormone-Related Protein Peptide Hormones - blood Radiography
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Zusammenfassung:	Hypercalcemia and osteolytic bone lesion are important complications in the prognosis of patients with adult T cell leukemia/lymphoma (ATL). We report a 61‐year‐old Japanese woman who died of ATL and had multiple osteolytic lesions and pathological fractures of her extremities. Highly increased serum levels of Interleukin‐6 (IL‐6) and a parathyroid hormone‐related protein (PTHrP) together with a high level of serum calcium observed at the time of fractures suggested their contribution to the formation of the bone lesions.
ISSN:	0385-2407 1346-8138
DOI:	10.1111/j.1346-8138.2002.tb00195.x