Comparison of the bactericidal activity of clindamycin and metronidazole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group

Time-kill kinetic methodology was used to evaluate the bactericidal activity of cefoxitin, cefotetan, clindamycin, and metronidizole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group. Overall, metronidazole was the most bactericidal agent, with all isol...

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Veröffentlicht in:Diagnostic microbiology and infectious disease 1991-09, Vol.14 (5), p.377-382
Hauptverfasser: Stratton, Charles W., Weeks, Lyndell S., Aldridge, Kenneth E.
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Sprache:eng
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Zusammenfassung:Time-kill kinetic methodology was used to evaluate the bactericidal activity of cefoxitin, cefotetan, clindamycin, and metronidizole against cefoxitin-susceptible and cefoxitin-resistant isolates of the Bacteroides fragilis group. Overall, metronidazole was the most bactericidal agent, with all isolates being killed with ⩽ 4 μg/ml at 24 hr. Clindamycin was the next most bactericidal agent, with 20 of 26 isolates being killed with < 16 μg/ml. Six isolates with clindamycin MICs ⩾ 64 μg/ml were not killed at 24 hr, with concentrations as high as 256 μg/ml. Cefoxitin and cefotetan were the least bactericidal agents tested. Seven isolates with MICs of ⩾ 64 μg/ml to each agent demonstrated a lack of killing at 24 hr, with concentrations of the respective agent as high as 256 μg/ml. At concentrations with either agent of 32 μg/ml, the remaining 19 isolates were killed at 24 hr. Of the six B. fragilis isolates resistant to clindamycin, four were also resistant to both cefoxitin and cefotetan. We conclude that in hospitals with cefoxitin-resistant B. fragilis group isolates, metronidazole would provide appropriate therapy.
ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(91)90064-M