Centrosome aberrations: cause or consequence of cancer progression?

Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But w...

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Veröffentlicht in:	Nature reviews. Cancer 2002-11, Vol.2 (11), p.815-825
1. Verfasser:	Nigg, Erich A
Format:	Artikel
Sprache:	eng
Schlagworte:	Causes of Cell Cycle Proteins - physiology Cell Division Centrosome - physiology Centrosome - ultrastructure Centrosomes Disease Progression Forecasting Health aspects Humans Metastasis Neoplasms - pathology Phosphorylation Protein Processing, Post-Translational Retinoblastoma Protein - physiology S Phase Spindle Apparatus - physiology Spindle Apparatus - ultrastructure Tumor Suppressor Protein p53 - physiology
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Zusammenfassung:	Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression?
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc924