Microbial Transformation of Rubijervine

Preparative-scale fermentation of rubijervine (1), the known 22,26-epiminocholestane Veratrum alkaloid, with Cunninghamella echinulata ATCC 9244 has resulted in the isolation of the new metabolites 7α-hydroxyrubijervine (2) and solanid-5-ene-3β,12α-diol-1-one (3). Structure elucidation of these meta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 2002, Vol.50(11), pp.1427-1429
Hauptverfasser:	Sayed, Khalid A. El, Dunbar, D. Chuck
Format:	Artikel
Sprache:	eng
Schlagworte:	7α-hydroxyrubijervine Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacokinetics biocatalysis Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation - physiology Cunninghamella - metabolism Cunninghamella echinulata Fermentation Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Methods. Procedures. Technologies Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments rubijervine solanid-5-ene-3β,12α-diol-1-one Veratrum alkaloid Veratrum Alkaloids - chemistry Veratrum Alkaloids - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Preparative-scale fermentation of rubijervine (1), the known 22,26-epiminocholestane Veratrum alkaloid, with Cunninghamella echinulata ATCC 9244 has resulted in the isolation of the new metabolites 7α-hydroxyrubijervine (2) and solanid-5-ene-3β,12α-diol-1-one (3). Structure elucidation of these metabolites was based primarily on 1D- and 2D-NMR analyses. The microbe C. echinulata ATCC 9244 was able to metabolize rings A and B of rubijervine but failed to metabolize rings C, D or its N-containing side chain, a finding which is analogous to the results of previous fermentation studies of steroidal alkaloids.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.50.1427