Mechanism of analgesic effect of clonidine in the treatment of dysmenorrhea

Mechanism of analgesic effect of clonidine in the treatment of dysmenorrhea

Clonidine substantially reduces the pain and cramping of dysmenorrhea. The mechanims for this effect may lie in increased release of analgesic opioids. It is suggested that perhaps a thromboxane synthetase inhibitor such as ginger which activates endorphin receptors may also be an effective treatmen...

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Veröffentlicht in:Medical hypotheses 1991-11, Vol.36 (3), p.223-224
1. Verfasser: Backon, J.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics - therapeutic use
Biological and medical sciences
Clonidine - therapeutic use
Dysmenorrhea - drug therapy
Dysmenorrhea - physiopathology
Endorphins - metabolism
Female
Humans
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Thromboxane-A Synthase - antagonists & inhibitors
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Beschreibung
Zusammenfassung:Clonidine substantially reduces the pain and cramping of dysmenorrhea. The mechanims for this effect may lie in increased release of analgesic opioids. It is suggested that perhaps a thromboxane synthetase inhibitor such as ginger which activates endorphin receptors may also be an effective treatment.
ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(91)90137-N