Did tRNA Synthetase Classes Arise on Opposite Strands of the Same Gene?

Structural homology of class II aminoacyl-tRNA synthetases to the HSP70 family and the existence of a gene whose sense and antisense strands code for a dehydrogenase and an HSP70 chaperonin justify reconsideration of a possible sense-antisense ancestry for the two synthetase classes.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2002-10, Vol.10 (4), p.705-708
Hauptverfasser:	Carter, Charles W., Duax, William L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acyl-tRNA Synthetases - chemistry Amino Acyl-tRNA Synthetases - classification Amino Acyl-tRNA Synthetases - genetics Evolution, Molecular Glutamate Dehydrogenase - chemistry Glutamate Dehydrogenase - genetics HSP70 Heat-Shock Proteins - chemistry HSP70 Heat-Shock Proteins - genetics Models, Molecular Molecular Sequence Data Protein Conformation RNA, Antisense - genetics Sequence Homology, Amino Acid
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Beschreibung
Zusammenfassung:	Structural homology of class II aminoacyl-tRNA synthetases to the HSP70 family and the existence of a gene whose sense and antisense strands code for a dehydrogenase and an HSP70 chaperonin justify reconsideration of a possible sense-antisense ancestry for the two synthetase classes.
ISSN:	1097-2765 1097-4164
DOI:	10.1016/S1097-2765(02)00688-3