Soluble α-Amino Acid Salts in Acetonitrile:  Practical Technology for the Production of Some Dipeptides

Soluble α-Amino Acid Salts in Acetonitrile:  Practical Technology for the Production of Some Dipeptides

α-Amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibito...

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Veröffentlicht in:Organic letters 2002-11, Vol.4 (23), p.4005-4008
Hauptverfasser: Palomo, Claudio, Palomo, Antonio L, Palomo, Francisco, Mielgo, Antonia
Format: Artikel
Sprache:eng
Schlagworte:
Acetonitriles
Amino Acids - chemistry
Chromatography, High Pressure Liquid
Dipeptides - chemical synthesis
Models, Molecular
Molecular Conformation
Salts
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Zusammenfassung:α-Amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol020136x