Role of Cyclooxygenase-2 in the Prolonged Regulation of Renal Function

ABSTRACT—The role of cyclooxygenase-2 (COX-2) in the prolonged regulation of renal function was evaluated during changes in sodium intake and reduction of NO synthesis. It was evaluated in conscious dogs by administering a selective inhibitor (nimesulide) during 8 consecutive days. Nimesulide admini...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-11, Vol.40 (5), p.721-728
Hauptverfasser:	Roig, Francisco, Llinás, Maria T, López, Ruth, Salazar, F Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - blood Animals Biological and medical sciences Blood Flow Velocity - drug effects Blood Pressure - drug effects Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Dogs Female Fundamental and applied biological sciences. Psychology Glomerular Filtration Rate - drug effects Infusions, Intravenous Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Kidney - blood supply Kidney - drug effects Kidney - metabolism Kidney Function Tests Models, Animal Nitric Oxide - metabolism Potassium - blood Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - urine Renal Circulation - drug effects Renin - blood Sodium - blood Sodium - metabolism Sodium - urine Sodium Chloride - administration & dosage Sodium, Dietary - pharmacology Sulfonamides - pharmacology Time Factors Vasoconstriction - drug effects Vasoconstriction - physiology Vertebrates: urinary system
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Zusammenfassung:	ABSTRACT—The role of cyclooxygenase-2 (COX-2) in the prolonged regulation of renal function was evaluated during changes in sodium intake and reduction of NO synthesis. It was evaluated in conscious dogs by administering a selective inhibitor (nimesulide) during 8 consecutive days. Nimesulide administration to dogs with normal or high sodium load did not modify glomerular filtration rate but reduced renal blood flow (16%;P 25% when nimesulide was administered to dogs with a reduced NO synthesis. During low sodium intake, COX-2 inhibition elicited a decrease (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.0000036451.76323.29