Correction of L-NAME-induced disturbances in DNA synthesis and free radical oxidation in respiratory organs of newborn albino rats with dalargin

Intraperitoneal injections of L-NAME (5 injections, 9.3 x 10(-5) mol/kg each) to albino rats from the 2nd to 6th day of life inhibited DNA synthesis in epithelial cells, stimulated this process in bronchial smooth muscle cells, and intensified free radical oxidation in the lungs. Dalargin administered in a dose of 1.4 x 10(-7) mol/kg 30 min after treatment with NG-nitro-L-arginine methyl ester abolished its effect on epithelial cells and attenuated changes in smooth muscle cells. Correcting activity of dalargin is associated with its antiradical and antioxidant properties.