DICER-LIKE1: blind men and elephants in Arabidopsis development

Genetic studies of embryo, ovule and flower development in Arabidopsis thaliana have led to the independent isolation of different mutant alleles of a single gene ( SIN1/ SUS1/ CAF, now renamed DCL1) that encodes a complex RNA-processing enzyme. DCL1 shows similarity to the Dicer group of genes, whi...

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Veröffentlicht in:	Trends in plant science 2002-11, Vol.7 (11), p.487-491
Hauptverfasser:	Schauer, Stephen E, Jacobsen, Steven E, Meinke, David W, Ray, Animesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biological and medical sciences CAF Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism DCL1 Development Dicer dsRNA Endoribonucleases - genetics Endoribonucleases - metabolism Flowers - genetics Flowers - growth & development Fundamental and applied biological sciences. Psychology Genes, Plant - genetics Mutation Plant growth. Development of the storage organs Plant physiology and development Ribonuclease III RNA Interference RNA silencing RNA, Plant - genetics RNA, Plant - metabolism RNAi Seeds - genetics Seeds - growth & development SIN1 SUS1 Vegetative apparatus, growth and morphogenesis. Senescence
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Zusammenfassung:	Genetic studies of embryo, ovule and flower development in Arabidopsis thaliana have led to the independent isolation of different mutant alleles of a single gene ( SIN1/ SUS1/ CAF, now renamed DCL1) that encodes a complex RNA-processing enzyme. DCL1 shows similarity to the Dicer group of genes, which are required for RNA silencing in Drosophila and Caenorhabditis. These recent findings identify a novel but conserved mechanism of post-transcriptional gene regulation that is important for development in eukaryotes. DICER-LIKE1 illuminates a central regulatory pathway for Arabidopsis development-recent studies reveal a novel mechanism of post-transcriptional gene regulation mediated by RNA silencing.
ISSN:	1360-1385 1878-4372
DOI:	10.1016/S1360-1385(02)02355-5