Ardisiphenols and Other Antioxidant Principles from the Fruits of Ardisia colorata

Novel alkylphenols, ardisiphenols A—C (1—3) and a novel bergenin derivative, demethoxybergenin (10) were isolated from the fruits of Ardisia colorata (Myrsinaceae), together with known alkylresorcinols (4—6), embelin (7), myricetin (8), quercetin (9), bergenin (11), norbergenin (12), kaempferol (13)...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2002, Vol.50(11), pp.1484-1487
Hauptverfasser:	Sumino, Megumi, Sekine, Toshikazu, Ruangrungsi, Nijsiri, Igarashi, Kazuei, Ikegami, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant Antioxidants - chemistry Antioxidants - isolation & purification Ardisia - chemistry Ardisia colorata ardisiphenol bergenin Biological and medical sciences cytotoxicity Fruit - chemistry General pharmacology Medical sciences Myrsinaceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Resorcinols - chemistry Resorcinols - isolation & purification
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Zusammenfassung:	Novel alkylphenols, ardisiphenols A—C (1—3) and a novel bergenin derivative, demethoxybergenin (10) were isolated from the fruits of Ardisia colorata (Myrsinaceae), together with known alkylresorcinols (4—6), embelin (7), myricetin (8), quercetin (9), bergenin (11), norbergenin (12), kaempferol (13), quercetin-3-O-β-D-glucopyranoside (14) and gallic acid (15). Their structures were determined by NMR, MS(/MS) analyses and other spectroscopic methods. Ardisiphenols showed moderate scavenging activities toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and showed cytotoxicity against the murine breast cancer cell line, FM3A.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.50.1484