$Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae)$

Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae)

A crude ethanol extract and hexane fraction from Morinda citrifolia Linn. (Rubiaceae) show antitubercular activity. The major constituents of the hexane fraction are E‐phytol, cycloartenol, stigmasterol, β‐sitosterol, campesta‐5,7,22‐trien‐3β‐ol and the ketosteroids stigmasta‐4‐en‐3‐one and stigmast...

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Veröffentlicht in:	Phytotherapy research 2002-11, Vol.16 (7), p.683-685
Hauptverfasser:	Saludes, Jonel P., Garson, Mary J., Franzblau, Scott G., Aguinaldo, Alicia M.
Format:	Artikel
Sprache:	eng
Schlagworte:	antitubercular activity Antitubercular Agents - administration & dosage Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Chromatography, High Pressure Liquid epidioxysterols Humans ketosteroids Microbial Sensitivity Tests Morinda Morinda citrifolia Mycobacterium tuberculosis - classification Mycobacterium tuberculosis - drug effects phytol Phytotherapy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves
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Beschreibung
Zusammenfassung:	A crude ethanol extract and hexane fraction from Morinda citrifolia Linn. (Rubiaceae) show antitubercular activity. The major constituents of the hexane fraction are E‐phytol, cycloartenol, stigmasterol, β‐sitosterol, campesta‐5,7,22‐trien‐3β‐ol and the ketosteroids stigmasta‐4‐en‐3‐one and stigmasta‐4‐22‐dien‐3‐one. E‐Phytol, a mixture of the two ketosteroids, and the epidioxysterol derived from campesta‐5,7,22‐trien‐3β‐ol all show pronounced antitubercular activity. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1003