Electron paramagnetic resonance studies of the effects of tri-n-butyltin on the physical state of proteins and lipids in erythrocyte membranes
Alkyltin compounds have been used as antioxidants in rubber products, surface disinfectants, biocides, and polymer stabilizers. Tributyltin (TBT) compounds are mainly used as biocidal agents. The erythrocyte membrane has served as a useful model for neurotoxicity, cytotoxicity, and generalized membr...
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| Veröffentlicht in: | Chemical research in toxicology 1991-03, Vol.4 (2), p.141-143 |
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| container_title | Chemical research in toxicology |
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| creator | Butterfield, D. Allan Schneider, Andrew M Rangachari, Anuradha |
| description | Alkyltin compounds have been used as antioxidants in rubber products, surface disinfectants, biocides, and polymer stabilizers. Tributyltin (TBT) compounds are mainly used as biocidal agents. The erythrocyte membrane has served as a useful model for neurotoxicity, cytotoxicity, and generalized membrane defects. The physical state of and interactions among the constituent membrane proteins, lipids, and carbohydrates can be monitored reliably by the technique of electron paramagnetic resonance (EPR) through the incorporation of an appropriate spin label. We report here the results of spin labeling investigation of the effects of TBT on the physical state of membrane proteins and lipids. |
| doi_str_mv | 10.1021/tx00020a002 |
| format | Article |
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Allan</creatorcontrib><creatorcontrib>Schneider, Andrew M</creatorcontrib><creatorcontrib>Rangachari, Anuradha</creatorcontrib><title>Electron paramagnetic resonance studies of the effects of tri-n-butyltin on the physical state of proteins and lipids in erythrocyte membranes</title><title>Chemical research in toxicology</title><addtitle>Chem. Res. Toxicol</addtitle><description>Alkyltin compounds have been used as antioxidants in rubber products, surface disinfectants, biocides, and polymer stabilizers. Tributyltin (TBT) compounds are mainly used as biocidal agents. The erythrocyte membrane has served as a useful model for neurotoxicity, cytotoxicity, and generalized membrane defects. The physical state of and interactions among the constituent membrane proteins, lipids, and carbohydrates can be monitored reliably by the technique of electron paramagnetic resonance (EPR) through the incorporation of an appropriate spin label. 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Toxic occupational diseases</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>E.S.R</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Erythrocyte Membrane - chemistry</subject><subject>Erythrocyte Membrane - drug effects</subject><subject>erythrocytes</subject><subject>Humans</subject><subject>Lipid Bilayers - chemistry</subject><subject>Lipid Metabolism</subject><subject>lipids</subject><subject>Lipids - chemistry</subject><subject>Medical sciences</subject><subject>membrane proteins</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - drug effects</subject><subject>metals</subject><subject>Metals and various inorganic compounds</subject><subject>Spin Labels</subject><subject>Toxicology</subject><subject>Trialkyltin Compounds - pharmacology</subject><issn>0893-228X</issn><issn>1520-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1rFTEUBuAgSr1WV66FbNSFjOZrMpmllPpBixZ6BXfh3EziTZ3JTJMMdP6Ev9lc5mJdCG4SwnlyeDkHoeeUvKWE0Xf5jhDCCJTjAdrQmpGqJpQ8RBuiWl4xpr4_Rk9SuiGElg_NCTqhUgpWiw36dd5bk-MY8AQRBvgRbPYGR5vGAMFYnPLceZvw6HDeW2ydK359Rl-Fajfnpc8-4NLiAKb9kryBvnyEbA9uimO2PiQMocO9n3yXcPE2LnkfR7MUNdhhFyHY9BQ9ctAn--x4n6JvH863Z5-qy68fP5-9v6yAc5IryWvBjOha1XVtp4zrVMMc2wEoYxQzyopW1E7RBiQH5bqat7zhrrU1g8Y5foperX1LuNvZpqwHn4zt-xJinJNumBSSiPa_kEpKJJOkwDcrNHFMKVqnp-gHiIumRB_WpP9aU9Evjm3n3WC7e7vupdRfHuuQyjBdGY7x6Z61kgpe0-Kq1fmU7d2fOsSfWja8qfX26lqLq-0XeXF9oQ8pX68eTNI34xxDmfI_E_4G_VC4yQ</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Butterfield, D. 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| ispartof | Chemical research in toxicology, 1991-03, Vol.4 (2), p.141-143 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Biological and medical sciences Blood Proteins - chemistry Blood Proteins - drug effects cell membranes Chemical and industrial products toxicology. Toxic occupational diseases Chemical Phenomena Chemistry, Physical E.S.R Electron Spin Resonance Spectroscopy Erythrocyte Membrane - chemistry Erythrocyte Membrane - drug effects erythrocytes Humans Lipid Bilayers - chemistry Lipid Metabolism lipids Lipids - chemistry Medical sciences membrane proteins Membrane Proteins - chemistry Membrane Proteins - drug effects metals Metals and various inorganic compounds Spin Labels Toxicology Trialkyltin Compounds - pharmacology |
| title | Electron paramagnetic resonance studies of the effects of tri-n-butyltin on the physical state of proteins and lipids in erythrocyte membranes |
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