Direct determination of ranitidine and famotidine by CE in serum, urine and pharmaceutical formulations

A simple and sensitive capillary electrophoresis method using UV detection has been developed for the direct determination of ranitidine (RANT) and famotidine (FAMT) in serum, urine and pharmaceutical formulations. A buffer consisting of 60 mM phosphate buffer adjusted to pH 6.5 was found to provide...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2002-11, Vol.30 (4), p.1055-1061
Hauptverfasser:	Pérez-Ruiz, Tomás, Martı́nez-Lozano, C, Tomás, V, Bravo, E, Galera, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Capillary electrophoresis Chemistry, Pharmaceutical Electrophoresis, Capillary - methods Famotidine Famotidine - blood Famotidine - chemistry Famotidine - urine General pharmacology Medical sciences Pharmaceutical formulations Pharmacology. Drug treatments Ranitidine Ranitidine - blood Ranitidine - chemistry Ranitidine - urine Serum Urine
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Beschreibung
Zusammenfassung:	A simple and sensitive capillary electrophoresis method using UV detection has been developed for the direct determination of ranitidine (RANT) and famotidine (FAMT) in serum, urine and pharmaceutical formulations. A buffer consisting of 60 mM phosphate buffer adjusted to pH 6.5 was found to provide a very efficient and stable electrophoretic system for the analysis of both drugs. The detection limits obtained were 0.088 μg ml −1 for RANT and 0.16 μg ml −1 for FAMT.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/S0731-7085(02)00444-2