Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

The novel iodinated radioligand, serotonin-5-O-carboxymethyl-glycyl[125I] tyrosinamide, was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of th...

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Veröffentlicht in:	European journal of pharmacology 1991-09, Vol.202 (1), p.89-91
Hauptverfasser:	BRUINVELS, A. T, LANDWEHRMEYER, B, WAEBER, C, PALACIOS, J. M, HOYER, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dipeptides Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Iodine Radioisotopes Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin - analogs & derivatives Substantia Nigra - drug effects Substantia Nigra - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	The novel iodinated radioligand, serotonin-5-O-carboxymethyl-glycyl[125I] tyrosinamide, was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(91)90257-Q