The liver X receptor gene team: Potential new players in atherosclerosis

The liver X receptor gene team: Potential new players in atherosclerosis

Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has implicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modul...

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Veröffentlicht in:Nature medicine 2002-11, Vol.8 (11), p.1243-1248
Hauptverfasser: Mangelsdorf, David J, Repa, Joyce J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Arteriosclerosis - genetics
Atherosclerosis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Care and treatment
Cell receptors
Control
DNA-Binding Proteins
Genetic aspects
Health aspects
Infectious Diseases
Liver X Receptors
Low density lipoproteins
Metabolic Diseases
Mice
Molecular Medicine
Neurosciences
Orphan Nuclear Receptors
Receptors, Cytoplasmic and Nuclear - genetics
review-article
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Zusammenfassung:Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has implicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.
ISSN:1078-8956
1546-170X
DOI:10.1038/nm1102-1243