Ubiquitin and the synapse

Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of sy...

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Veröffentlicht in:	Nature reviews. Neuroscience 2002-11, Vol.3 (11), p.854-861
Hauptverfasser:	Hegde, Ashok N, DiAntonio, Aaron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cell Membrane - metabolism Cyclin-dependent kinases Cysteine Endopeptidases - metabolism DNA methylation Enzymes Epigenetics Genes Humans Kinases Multienzyme Complexes - metabolism Nervous system Nervous System - growth & development Nervous System - metabolism Neuronal Plasticity - physiology Neurosciences Phosphorylation Physiology Presynaptic Terminals - metabolism Proteasome Endopeptidase Complex Protein Transport - physiology Proteins Synaptic Transmission - physiology Transcription factors Ubiquitin - metabolism
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Zusammenfassung:	Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections. Here, we discuss the myriad ways in which ubiquitin functions to sculpt synapses during development, and to remodel synapses for the acquisition and storage of memory.
ISSN:	1471-003X 1471-0048 1471-0048 1469-3178
DOI:	10.1038/nrn961