When ligand becomes receptor-tolerance via B7 signaling on DCs

CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2002-11, Vol.3 (11), p.1056-1057
Hauptverfasser:	Bluestone, Jeffrey A, Finger, Erik B
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Antigens, CD Antigens, Differentiation - genetics Antigens, Differentiation - immunology B7-1 Antigen - drug effects B7-1 Antigen - immunology Biomedical and Life Sciences Biomedicine CD28 Antigens - immunology CTLA-4 Antigen Cytotoxicity, Immunologic Dendritic Cells - immunology Enzyme Induction Humans Immune Tolerance - immunology Immunoconjugates - genetics Immunoconjugates - pharmacology Immunology Infectious Diseases Interferon-gamma - secretion Ligands Lymphocyte Activation - immunology Mice Mice, Transgenic Models, Immunological news-and-views Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - pharmacology T-Lymphocytes, Cytotoxic - immunology Tryptophan Oxygenase - physiology
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Beschreibung
Zusammenfassung:	CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/ni1102-1056