A new regulatory pathway for fragile X syndrome?

A new regulatory pathway for fragile X syndrome?

One out of every 4,500 males suffers cognitive impairment due to alterations in the fragile X gene. The gene has a complicated biology, and it may have just gotten a bit more complex. The fragile X gene product in flies could play a role in regulation by small RNA molecules.

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Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2002-11, Vol.8 (11), p.1204-1205
Hauptverfasser: Hansen, R. Scott, Laird, Charles D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Drosophila - genetics
Fragile X Mental Retardation Protein
Fragile X syndrome
Fragile X Syndrome - genetics
Genetic aspects
Health aspects
Humans
Male
Methylation
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Risk factors
RNA - physiology
RNA-Binding Proteins
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Beschreibung
Zusammenfassung:One out of every 4,500 males suffers cognitive impairment due to alterations in the fragile X gene. The gene has a complicated biology, and it may have just gotten a bit more complex. The fragile X gene product in flies could play a role in regulation by small RNA molecules.
ISSN:1078-8956
1546-170X
DOI:10.1038/nm1102-1204