Diversity in HLA-DR4-related DR,DQ haplotypes in Australia, Oceania, and China

The relative distributions of 12 HLA-DR4-related DRB1 alleles in indigenous populations of Australia, Melanesia, Micronesia, Polynesia, and northern and southern China have been determined by analysis of oligonucleotide hybridization patterns of 406 examples of HLA-DR4. DRB1 ∗0405 and DRB1 ∗0410 wer...

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Veröffentlicht in:Human immunology 1991-12, Vol.32 (4), p.269-276
Hauptverfasser: Gao, X., Serjeantson, S.W.
Format: Artikel
Sprache:eng
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Zusammenfassung:The relative distributions of 12 HLA-DR4-related DRB1 alleles in indigenous populations of Australia, Melanesia, Micronesia, Polynesia, and northern and southern China have been determined by analysis of oligonucleotide hybridization patterns of 406 examples of HLA-DR4. DRB1 ∗0405 and DRB1 ∗0410 were common DR4 alleles in Australian aborigines and in Melanesians, while DRB1 ∗0403 was the predominant DR4 allele in coastal Melanesians, Micronesians, and Polynesians; DRB1 ∗0406 was confined to Chinese. A novel DR4 allele, found in 30% of DR4-positive Australian aborigines but exclusive to one aboriginal population, was a combination of DRB1 ∗04 and 0803 nucleotide sequences and was carried on a haplotype with DR4-like DQ linkage arrangements. DQA1 and DQB1 typing generated 12 DR4-related haplotypes; the population distributions of these reflected the ancestral affinities of aborigines and Melanesians, the overlaping of coastal Melanesia with pre-Polynesian DR4 alleles and the colonization of Micronesia by an independent, non-Polynesian group. DR4-related autoimmune disorders such as rheumatoid arthritis (RA) and insulin-dependent diabetes mellitus (IDDM) are virtually unknown in indigenous populations of Australian and Oceania and this study confirmed that high-risk RA determinants, Dw4 and Dw14, occurred rarely. However, the DQw8 allele, thought particularly to predispose to IDDM, was present in the majority of DR4-positive Polynesians and Micronesians.
ISSN:0198-8859
1879-1166
DOI:10.1016/0198-8859(91)90090-V