Ruthenium-Catalyzed S-Propargylation of Thiols Enables the Rapid Synthesis of Propargylic Sulfides

Ruthenium-Catalyzed S-Propargylation of Thiols Enables the Rapid Synthesis of Propargylic Sulfides

A new and highly efficient catalytic system based on CpRuClL2 is proposed for the S-propargylation of thiols by propargylic carbonates under neutral conditions, in which specific requirements inherent to the different reactivities of aliphatic and aromatic thiols are achieved by tuning both the natu...

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Veröffentlicht in:Journal of the American Chemical Society 2002-11, Vol.124 (44), p.12960-12961
Hauptverfasser: Kondo, Teruyuki, Kanda, Yusuke, Baba, Atsushi, Fukuda, Kenji, Nakamura, Ayako, Wada, Kenji, Morisaki, Yasuhiro, Mitsudo, Take-aki
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemical synthesis
Carbamates - chemistry
Catalysis
Chemistry
Exact sciences and technology
Organic chemistry
Organometallic Compounds - chemistry
Ruthenium - chemistry
Sulfhydryl Compounds - chemistry
Sulfides - chemical synthesis
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Beschreibung
Zusammenfassung:A new and highly efficient catalytic system based on CpRuClL2 is proposed for the S-propargylation of thiols by propargylic carbonates under neutral conditions, in which specific requirements inherent to the different reactivities of aliphatic and aromatic thiols are achieved by tuning both the nature of the ancillary ligand L and the experimental conditions.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja027750o