Study of the skin concentrations after administration of the various phototoxic drugs

The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the conce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Yonsei medical journal 1991-09, Vol.32 (3), p.231-236
Hauptverfasser:	Park, Y K, Hann, S K, Cho, M Y, Kim, H J, Shim, S C, Choi, S J, Yun, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Oral Animals Guinea Pigs Methoxsalen - administration & dosage Methoxsalen - analysis PUVA Therapy Skin - chemistry Trioxsalen - administration & dosage Trioxsalen - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP.
ISSN:	0513-5796
DOI:	10.3349/ymj.1991.32.3.231