Insulin-Carrying Microspheres, in Vitro Studies
Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro.The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1991/07/25, Vol.39(7), pp.1892-1893 |
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| container_end_page | 1893 |
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| container_issue | 7 |
| container_start_page | 1892 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 39 |
| creator | GIZURARSON, Sveinbjorn BECHGAARD, Erik |
| description | Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro.The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w. Insulin did not show any sorption into the matrix of the starch microspheres. The release characteristics were analyzed by high performance liquid chromatography. About 80% was released within 5-10 min from albumin microspheres and starch microspheres, respectively |
| doi_str_mv | 10.1248/cpb.39.1892 |
| format | Article |
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Insulin did not show any sorption into the matrix of the starch microspheres. The release characteristics were analyzed by high performance liquid chromatography. About 80% was released within 5-10 min from albumin microspheres and starch microspheres, respectively</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.39.1892</identifier><identifier>PMID: 1777942</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>adsorption ; Biological and medical sciences ; General pharmacology ; Humans ; insulin ; Insulin - administration & dosage ; Insulin - chemistry ; Medical sciences ; microsphere ; Microspheres ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; release ; sorption ; Starch</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1991/07/25, Vol.39(7), pp.1892-1893</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5522-9c4fcffd997d84114d99f304a1a417a106c93b3c9e86ada078d252f89ddb9723</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5437700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1777942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIZURARSON, Sveinbjorn</creatorcontrib><creatorcontrib>BECHGAARD, Erik</creatorcontrib><title>Insulin-Carrying Microspheres, in Vitro Studies</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro.The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w. Insulin did not show any sorption into the matrix of the starch microspheres. The release characteristics were analyzed by high performance liquid chromatography. About 80% was released within 5-10 min from albumin microspheres and starch microspheres, respectively</description><subject>adsorption</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>insulin</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - chemistry</subject><subject>Medical sciences</subject><subject>microsphere</subject><subject>Microspheres</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>release</subject><subject>sorption</subject><subject>Starch</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAchoMoc05PnoWB4kW75ZekTXOU-TWYeHB4DVmabhldO5P2sP_elI4NvHhJAu_D-5IHoWvAIyAsHevtYkTFCFJBTlAfKONRTAg9RX2MsYgITeg5uvB-jTGJMac91APOuWCkj8bT0jeFLaOJcm5ny-Xww2pX-e3KOOMfh7YcftvaVcOvusms8ZfoLFeFN1f7e4Dmry_zyXs0-3ybTp5mkY7DdiQ0y3WeZ0LwLGUALLxyipkCxYArwIkWdEG1MGmiMoV5mpGY5KnIsoXghA7QfVe7ddVPY3wtN9ZrUxSqNFXjJSdJaMPwLwgJACfAA3j7B1xXjSvDHySwBBPKYp4G6qGjWgfemVxund0ot5OAZStbBtmSCtnKDvTNvrNZbEx2ZDu7Ib_b58prVeROldr6AxYzyjnGAXvusLWv1dIccuVqqwvTToKI03aWd0e7foxXyklT0l_FTpxe</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>GIZURARSON, Sveinbjorn</creator><creator>BECHGAARD, Erik</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Insulin-Carrying Microspheres, in Vitro Studies</title><author>GIZURARSON, Sveinbjorn ; BECHGAARD, Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5522-9c4fcffd997d84114d99f304a1a417a106c93b3c9e86ada078d252f89ddb9723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>adsorption</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>insulin</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - chemistry</topic><topic>Medical sciences</topic><topic>microsphere</topic><topic>Microspheres</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>release</topic><topic>sorption</topic><topic>Starch</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIZURARSON, Sveinbjorn</creatorcontrib><creatorcontrib>BECHGAARD, Erik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIZURARSON, Sveinbjorn</au><au>BECHGAARD, Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-Carrying Microspheres, in Vitro Studies</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1991</date><risdate>1991</risdate><volume>39</volume><issue>7</issue><spage>1892</spage><epage>1893</epage><pages>1892-1893</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro.The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w. Insulin did not show any sorption into the matrix of the starch microspheres. The release characteristics were analyzed by high performance liquid chromatography. About 80% was released within 5-10 min from albumin microspheres and starch microspheres, respectively</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1777942</pmid><doi>10.1248/cpb.39.1892</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1991/07/25, Vol.39(7), pp.1892-1893 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72630401 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | adsorption Biological and medical sciences General pharmacology Humans insulin Insulin - administration & dosage Insulin - chemistry Medical sciences microsphere Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments release sorption Starch |
| title | Insulin-Carrying Microspheres, in Vitro Studies |
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