Insulin-Carrying Microspheres, in Vitro Studies

Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro.The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/07/25, Vol.39(7), pp.1892-1893
Hauptverfasser:	GIZURARSON, Sveinbjorn, BECHGAARD, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	adsorption Biological and medical sciences General pharmacology Humans insulin Insulin - administration & dosage Insulin - chemistry Medical sciences microsphere Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments release sorption Starch
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Loading and release characteristics of insulin-carrying albumin and starch microspheres have been studied in vitro.The sorption characteristics of 125I-labelled insulin onto albumin microspheres were studied and were found to be completed within 5h, and the loading capacity was found to be 0.14% w/w. Insulin did not show any sorption into the matrix of the starch microspheres. The release characteristics were analyzed by high performance liquid chromatography. About 80% was released within 5-10 min from albumin microspheres and starch microspheres, respectively
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.1892