Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues

Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues

Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phytoalexins cyclobrassinin, brassilexin (previously isolated from vegetables of the Cruciferae family) and their synthetic analogues 5-methoxybrassilexin and homocyclobrassinin. The most biologic...

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Veröffentlicht in:Zeitschrift für Naturforschung C. A journal of biosciences 1991-07, Vol.46 (7), p.706-708
Hauptverfasser: Tempête, Christiane, Devys, Michel, Barbier, Michel
Format: Artikel
Sprache:eng
Schlagworte:
Cancer Cells
Cell Division - drug effects
Cell Survival - drug effects
Cruciferae
Growth Inhibition
Humans
Indoles - pharmacology
KB Cells
Phytoalexins
Plant Extracts - pharmacology
Sesquiterpenes
Structure-Activity Relationship
Sulfur
Terpenes
Vegetables
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Beschreibung
Zusammenfassung:Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phytoalexins cyclobrassinin, brassilexin (previously isolated from vegetables of the Cruciferae family) and their synthetic analogues 5-methoxybrassilexin and homocyclobrassinin. The most biologically active of these products is brassilexin (LD = 8 μg/ml).
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-1991-7-831