Critical Role of Endothelial Nitric Oxide Synthase and Cyclooxygenase in Response of Rabbit Basilar Artery to Serotonin

The modes of action of serotonin (5-HT) on the tone of the rabbit basilar artery were investigated in vitro with the aim of determining the exact role of the endothelium. After sacrificing the animal under pentobarbital anesthesia, 3-mm segments of the artery were removed and mounted in a 5-ml myogr...

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Veröffentlicht in:	Japanese Journal of Pharmacology 2002, Vol.90(1), pp.67-76
Hauptverfasser:	Sercombe, Richard, Sercombe, Christine, Oudart, Nicole, Seylaz, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basilar Artery - drug effects Basilar Artery - enzymology Cerebral artery Dose-Response Relationship, Drug Eicosanoid In Vitro Techniques Indomethacin Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type III Nitro-arginine Prostaglandin-Endoperoxide Synthases - physiology Rabbits Serotonin - pharmacology Thromboxane synthase Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilation - drug effects Vasodilation - physiology
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Zusammenfassung:	The modes of action of serotonin (5-HT) on the tone of the rabbit basilar artery were investigated in vitro with the aim of determining the exact role of the endothelium. After sacrificing the animal under pentobarbital anesthesia, 3-mm segments of the artery were removed and mounted in a 5-ml myograph for isometric tension recording. Vessels precontracted by histamine were relaxed by acetylcholine. Mean maximum relaxation at 10-4 M was reduced from 79% to 22% (P
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.90.67