Effects of furyl-dihydropyridines I on lipid peroxides of ischemic myocardium and ATPases activity of erythrocyte membranes in rats

Acute myocardial ischemia and reperfusion in rats increased glutamic oxalacetic transaminase (GOT), non-esterified fatty acid (FFA), malondialdehyde (MDA) content. Furyl-dihydropyridines I 10 mg.kg-1 decreased the release of GOT, FFA, MDA of ischemic myocardium, and prevent ischemia-reperfusion arrh...

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Veröffentlicht in:	Zhōngguó yàolĭ xuébào 1991-05, Vol.12 (3), p.253-256
Hauptverfasser:	Liu, D Q, Pang, Z Q, Zhao, D H, Sheng, B H
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Aspartate Aminotransferases - blood Calcium Channel Blockers Calcium-Transporting ATPases - blood Dihydropyridines - pharmacology Dihydropyridines - therapeutic use Erythrocyte Membrane - enzymology Fatty Acids, Nonesterified - blood Malondialdehyde - blood Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Rats Sodium-Potassium-Exchanging ATPase - blood
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Zusammenfassung:	Acute myocardial ischemia and reperfusion in rats increased glutamic oxalacetic transaminase (GOT), non-esterified fatty acid (FFA), malondialdehyde (MDA) content. Furyl-dihydropyridines I 10 mg.kg-1 decreased the release of GOT, FFA, MDA of ischemic myocardium, and prevent ischemia-reperfusion arrhythmia. Furyl-dihydropyridines I increased Na, K-ATPase activity and N-acethylneuraminic acid (NANA) content of erythrocyte membranes, inhibited Ca-ATPase activity of erythrocyte membranes in rats. The results suggested that the mechanism of protecting the ischemic-reperfused myocardium might be associated with the inhibition of cellular lipid peroxidation and Ca-ATPase activity of cell membranes.
ISSN:	0253-9756