Sterol biosynthesis inhibitors: Their current status and modes of action

The mechanism of each of the reactions in the post‐squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.

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Bibliographische Detailangaben
Veröffentlicht in:	Lipids 1991-08, Vol.26 (8), p.584-597
1. Verfasser:	Mercer, E. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antifungal Agents - pharmacology Biological and medical sciences Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Fungi - drug effects Fungi - enzymology Molecular Structure Other biological molecules Plants - drug effects Plants - enzymology Squalene - metabolism Sterols - biosynthesis Sterols - chemistry
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Beschreibung
Zusammenfassung:	The mechanism of each of the reactions in the post‐squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.
ISSN:	0024-4201 1558-9307
DOI:	10.1007/BF02536422